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KMID : 0644120180310040110
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Journal of Oriental Gynecology
2018 Volume.31 No. 4 p.110 ~ p.127
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Traditional Herbal Medicine for Dysfunctional Uterine Bleeding versus Western Medicine: A Systematic Review of Randomized Controlled Trials
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Park Eo-Jin
Jo Hee-Geun
Choi Ji-Hyun
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Abstract
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Objectives: To evaluate the effectiveness and safety of traditional herbal medicine (THM) in the treatment of dysfunctional uterine bleeding (DUB) versus conventional western medicine.
Methods: Randomized Controlled Trials (RCTs) comparing THM vs. conventional western medicine for DUB, were obtained from PubMed, Cochrane Library, Embase, CNKI, RISS, NDSL, KISS and OASIS. The risk of bias was assessed by using Cochrane’s risk of bias tool.
Results: 16 RCTs with 1,659 patients were identified and reviewed. 10 RCTs reported THM was statistically effective than control group in effective rate. Also recurrent rate was estimated in 6 RCTs and was lower than control group. 7 studies observed adverse events (AEs) and severe AEs were not reported.
Conclusions: Despite several limitations, this review suggested that THM was safe and effective in the treatment of DUB. THM may also decrease the recurrence rate. However, this could not be proven conclusively. To ensure evidence-based clinical practice, more sternly designed trials are warranted.
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KEYWORD
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Dysfunctional Uterine Bleeding (DUB), Herbal Medicine, Chinese Herbal Medicine (CHM), Randomized Controlled Trial (RCT)
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